AI-1

• Catalog No.: SML0009
• CAS Number: 75483-04-4
• M. F.: C13H12ClNO3
• M. W.: 265.69228
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
• IUPAC Traditional name: ethyl 4-chloro-1-methyl-2-oxoquinoline-3-carboxylate
• Synonyms: Ethyl 4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate; 4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester

DATABASE IDS

• MDL Number: MFCD00634787
• CAS Number: 75483-04-4

PROPERTIES

• Empirical Formula (Hill Notation): C13H12ClNO3
• Purity: ≥98% (HPLC)
• Apperance: white to tan powder
• Solubility: DMSO: ≥15 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H317
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P280
• Risk Statements: 43
• Safety Statements: 36/37
• Storage Temperature: 2-8°C

DETAILS

Description (English)

Biochem/physiol Actions
AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2. Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.

Description (简体中文)

Biochem/physiol Actions
AI-1 promotes Nrf2 activation via the covalent modification of Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2. Biochemical studies indicate that an aromatic chloride present within the AI-1 molecule undergoes a nucleophilic aromatic substitution reaction with cysteine thiols of Keap1.