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CP-100356 monohydrochloride_Molecular_structure_CAS_142715-48-8)
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CP-100356 monohydrochloride

Catalog No. PZ0171 Name Sigma Aldrich
CAS Number 142715-48-8 Website http://www.sigmaaldrich.com
M. F. C31H37ClN4O6 Telephone 1-800-521-8956
M. W. 597.10168 Fax
Purity >98% (HPLC) Email
Storage Chembase ID: 154910

SYNONYMS

IUPAC name
4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxyquinazolin-2-amine hydrochloride
IUPAC Traditional name
4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxyquinazolin-2-amine hydrochloride
Synonyms
4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine monohydrochloride

DATABASE IDS

MDL Number MFCD00911858
CAS Number 142715-48-8

PROPERTIES

Empirical Formula (Hill Notation) C31H36N4O6 · HCl
Purity >98% (HPLC)
Apperance white to off-white powder
Solubility DMSO: >5 mg/mL
MSDS Link Download
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM).
Description (简体中文)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM).

REFERENCES