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Tolvaptan

Catalog No. T7455 Name Sigma Aldrich
CAS Number 150683-30-0 Website http://www.sigmaaldrich.com
M. F. C26H25ClN2O3 Telephone 1-800-521-8956
M. W. 448.9413 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 73268

SYNONYMS

IUPAC name
N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
IUPAC Traditional name
tolvaptan
Synonyms
OPC 41061
N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide

DATABASE IDS

CAS Number 150683-30-0
MDL Number MFCD09838782

PROPERTIES

Empirical Formula (Hill Notation) C26H25ClN2O3
Purity ≥98% (HPLC)
Apperance white to tan powder
Solubility DMSO: ≥15 mg/mL
MSDS Link Download
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Tolvaptan (OPC 41061) is a potent, orally active non-peptide vasopressin V2 selective antagonist. IC50 = 3 nM at the rat V2 receptor; 29 times more selective for the V2 than for V1a. Tolvaptan has also been shown to inhibit the development of polycystic kidney disease in several animal models.
Description (简体中文)
Biochem/physiol Actions
Tolvaptan (OPC 41061) is a potent, orally active non-peptide vasopressin V2 selective antagonist. IC50 = 3 nM at the rat V2 receptor; 29 times more selective for the V2 than for V1a. Tolvaptan has also been shown to inhibit the development of polycystic kidney disease in several animal models.

REFERENCES