PD184352

• Catalog No.: PZ0181
• CAS Number: 212631-79-3
• M. F.: C17H14ClF2IN2O2
• M. W.: 478.6595364
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
• IUPAC Traditional name: 2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
• Synonyms: CI-1040; 2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide

DATABASE IDS

• MDL Number: MFCD02683961
• CAS Number: 212631-79-3

PROPERTIES

• Empirical Formula (Hill Notation): C17H14ClF2IN2O2
• Purity: ≥98% (HPLC)
• Apperance: white to tan powder
• Solubility: DMSO: ≥30 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H400
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273
• Risk Statements: 50/53
• Safety Statements: 60-61
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.

Description (简体中文)

Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.