Bisdemethoxycurcumin

• Catalog No.: B6938
• M. F.: C19H16O4
• M. W.: 308.32794
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
• IUPAC Traditional name: 1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
• Synonyms: (1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

DATABASE IDS

• MDL Number: MFCD03419284

PROPERTIES

• Empirical Formula (Hill Notation): C19H16O4
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: ≥20 mg/mL
• Storage Temperature: 2-8°C
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10.

Description (简体中文)

Biochem/physiol Actions
Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10.