Tigecycline hydrate

• Catalog No.: PZ0021
• CAS Number: 1229002-07-6
• M. F.: C29H41N5O9
• M. W.: 603.66394
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (4S,4aS,5aR,12aS)-9-[2-(tert-butylamino)acetamido]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrate
• IUPAC Traditional name: tigecycline hydrate
• Synonyms: Tygacil; Tigecyclin; TBG-MINO; 9-t-Butylglycylamido-minocycline hydrate

DATABASE IDS

• CAS Number: 1229002-07-6

PROPERTIES

• Empirical Formula (Hill Notation): C29H39N5O8 · xH2O
• Purity: ≥98% (HPLC)
• Apperance: off-white to yellow-brown powder
• Optical Rotation: [α]/D -160 to 170°, c = 0.15 in methanol
• Solubility: DMSO: ≥3 mg/mL (warmed)
• GHS Signal Word: Danger
• GHS Hazard statements: H319-H360
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P201-P305 + P351 + P338-P308 + P313
• Risk Statements: 61-36-52-64
• RTECS: QI7619500
• Safety Statements: 13-36/37/39
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
air sensitive
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.

Description (简体中文)

Other Notes
air sensitive
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.