MDL 72527

• Catalog No.: M2949
• CAS Number: 93565-01-6
• M. F.: C12H22Cl2N2
• M. W.: 265.22248
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (buta-2,3-dien-1-yl)({4-[(buta-2,3-dien-1-yl)amino]butyl})amine dihydrochloride
• IUPAC Traditional name: buta-2,3-dien-1-yl[4-(buta-2,3-dien-1-ylamino)butyl]amine dihydrochloride
• Synonyms: N1,N4-Bis(2,3-butadienyl)-1,4-butanediamine hydrochloride; MDL-72527DA; N,N′-Bis(2,3-butadienyl)-1,4-butanediamine dihydrochloride; CPC-200

DATABASE IDS

• MDL Number: MFCD13152261
• CAS Number: 93565-01-6

PROPERTIES

• Empirical Formula (Hill Notation): C12 H20 N2·2 HCl
• Purity: ≥98% (HPLC)
• Apperance: light yellow to light brown powder
• Solubility: DMSO: ≥20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• Safety Statements: 26
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO). It blocks the production of H2O2 and increases the cells survival. Polyamine catabolism is one of the major causes of the ROS production of prostate cells in general and androgen-induced enhancement of ROS in androgen-dependent CaP cells in particular. Reports suggest that androgen stimulation of prostate cancer results in accumulation of ROS, which lead to progression of cancer, such progression is control by MDL 72527.

Description (简体中文)

Biochem/physiol Actions
MDL 72527is an inhibitor of polyamine oxidase (spermine oxidase SMO). It blocks the production of H2O2 and increases the cells survival. Polyamine catabolism is one of the major causes of the ROS production of prostate cells in general and androgen-induced enhancement of ROS in androgen-dependent CaP cells in particular. Reports suggest that androgen stimulation of prostate cancer results in accumulation of ROS, which lead to progression of cancer, such progression is control by MDL 72527.