RU7

• Catalog No.: R1408
• CAS Number: 355400-87-2
• M. F.: C14H11Br2NO6S
• M. W.: 481.11324
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-{5-[(2,3-dibromo-5-ethoxy-4-hydroxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetic acid
• IUPAC Traditional name: {5-[(2,3-dibromo-5-ethoxy-4-hydroxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl}acetic acid
• Synonyms: 5-[(2,3-Dibromo-5-ethoxy-4-hydroxyphenyl)methylene]-4-oxo-2-thioxo-3-thiazolidineacetic acid

DATABASE IDS

• CAS Number: 355400-87-2

PROPERTIES

• Empirical Formula (Hill Notation): C14H11Br2NO5S2
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Solubility: DMSO: ≥20 mg/mL
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
RU7 is a selective inhibitor of bacterial β-clamp interaction with DNA polymerase POL III, and an inhibitor of a DNA polymerase sliding clamp. Sliding clamps are proteins which function with diverse DNA polymerases, repair factors, and cell cycle-control proteins. RU7 binds to the peptide-binding pocket of the β-clamp and selectively inhibits Pol III, compared with Pol II and Pol IV.

Description (简体中文)

Biochem/physiol Actions
RU7 is a selective inhibitor of bacterial β-clamp interaction with DNA polymerase POL III, and an inhibitor of a DNA polymerase sliding clamp. Sliding clamps are proteins which function with diverse DNA polymerases, repair factors, and cell cycle-control proteins. RU7 binds to the peptide-binding pocket of the β-clamp and selectively inhibits Pol III, compared with Pol II and Pol IV.