COG 133 trifluoroacetate salt

• Catalog No.: C8624
• CAS Number: 514200-66-9(freebase)
• M. F.: C99H182F3N37O22
• M. W.: 2299.7342896
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: trifluoroacetic acid amino (2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-2-acetamido-4-methylpentanamido]pentanamido]-3-methylbutanamido]pentanamido]-4-methylpentanamido]propanamido]-3-hydroxypropanamido]-3-(1H-imidazol-5-yl)propanamido]-4-methylpentanamido]pentanamido]hexanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]hexanamido]-5-carbamimidamidopentanamido]-4-methylpentanamido]-4-methylpentanoate
• IUPAC Traditional name: trifluoroacetic acid amino (2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[(2S)-2-acetamido-4-methylpentanamido]pentanamido]-3-methylbutanamido]pentanamido]-4-methylpentanamido]propanamido]-3-hydroxypropanamido]-3-(3H-imidazol-4-yl)propanamido]-4-methylpentanamido]pentanamido]hexanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]hexanamido]-5-carbamimidamidopentanamido]-4-methylpentanamido]-4-methylpentanoate
• Synonyms: apoE(133-149); Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu- Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2; COG133; N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-Leucinamide; Ac- LRVRLASHLRKLRKRLL-NH2

DATABASE IDS

• CAS Number: 514200-66-9(freebase)
• MDL Number: MFCD18432706

PROPERTIES

• Empirical Formula (Hill Notation): C97H181N37O19 · xC2HF3O2
• Purity: ≥95% (HPLC)
• Apperance: white lyophilized
• Solubility: H2O: >1 mg/mL
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
COG 1333 or apoE(133-149) is a fragment of Apolipoprotein E (APOE) that mimics the functional anti-inflammatory and neuroprotective effects of the intact apoE protein. It was suggested that neuroprotective functions of the mimetic results from binding to the low-density lipoprotein receptor-related protein (LRP) or LDL receptors, and such binding results in inhibition of the N-methyl-D-aspartate (NMDA) receptor.

Description (简体中文)

Biochem/physiol Actions
COG 1333 or apoE(133-149) is a fragment of Apolipoprotein E (APOE) that mimics the functional anti-inflammatory and neuroprotective effects of the intact apoE protein. It was suggested that neuroprotective functions of the mimetic results from binding to the low-density lipoprotein receptor-related protein (LRP) or LDL receptors, and such binding results in inhibition of the N-methyl-D-aspartate (NMDA) receptor.