MST-312

• Catalog No.: M3949
• CAS Number: 368449-04-1
• M. F.: C20H16N2O6
• M. W.: 380.35084
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-[3-(2,3-dihydroxybenzamido)phenyl]-2,3-dihydroxybenzamide
• IUPAC Traditional name: N-[3-(2,3-dihydroxybenzamido)phenyl]-2,3-dihydroxybenzamide
• Synonyms: N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]

DATABASE IDS

• CAS Number: 368449-04-1

PROPERTIES

• Empirical Formula (Hill Notation): C20H16N2O6
• Purity: ≥98% (HPLC)
• Apperance: off-white to light tan powder
• Solubility: DMSO: ≥20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H400
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273
• Risk Statements: 50
• Safety Statements: 61
• Storage Temperature: 2-8°C
• German water hazard class: 2

DETAILS

Description (English)

Biochem/physiol Actions
MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.

Description (简体中文)

Biochem/physiol Actions
MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.