Pristimerin

• Catalog No.: P0020
• CAS Number: 1258-84-0
• M. F.: C30H40O4
• M. W.: 464.6362
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: methyl (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylate
• IUPAC Traditional name: pristimerin
• Synonyms: (9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26 -trinoroleana-1(10),3,5,7-tertraen-29-oic acid methyl ester

DATABASE IDS

• CAS Number: 1258-84-0
• MDL Number: MFCD01711331

PROPERTIES

• Empirical Formula (Hill Notation): C30H40O4
• Purity: ≥98% (HPLC)
• Apperance: orange powder
• Solubility: DMSO: ≥5 mg/mL
• Storage Condition: protect from light
• Storage Temperature: -20°C

DETAILS

Description (English)

Biochem/physiol Actions
More active than euphol against MGL, better activity with rat neurons, but less selective relative to similar enzymes. First MGL inhibitor to act reversibly, several others covalently bind to cysteine residues. Other studies involve multiply mylome, pristimerin inhibits NF-κB activation via inhibition of IKK-α or IKK-β. It is the methyl ester of celastrol (C0869).

Description (简体中文)

Biochem/physiol Actions
More active than euphol against MGL, better activity with rat neurons, but less selective relative to similar enzymes. First MGL inhibitor to act reversibly, several others covalently bind to cysteine residues. Other studies involve multiply mylome, pristimerin inhibits NF-κB activation via inhibition of IKK-α or IKK-β. It is the methyl ester of celastrol (C0869).