PKF118-310

• Catalog No.: K4394
• CAS Number: 84-82-2
• M. F.: C7H7N5O2
• M. W.: 193.16278
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4,7-dimethyl-4H,6H,7H,8H-pyrimido[4,5-e][1,2,4]triazine-6,8-dione
• IUPAC Traditional name: 4,7-dimethylpyrimido[4,5-e][1,2,4]triazine-6,8-dione
• Synonyms: Toxoflavin; 1,6-Dimethyl-pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione; Xanthothricin

DATABASE IDS

• CAS Number: 84-82-2

PROPERTIES

• Empirical Formula (Hill Notation): C7H7N5O2
• Purity: ≥98% (HPLC)
• Apperance: white to tan powder
• Solubility: DMSO: ≥15 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H300
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P264-P301 + P310
• Risk Statements: 28
• Safety Statements: 45-46
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.

Description (简体中文)

Biochem/physiol Actions
PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. The compound disrupts the Tcf4/b-catenin complex and inhibits expression of Tcf4 responsive genes. PKF118-310 inhibits expression of survivin and induces apoptosis in HCC, colon tumor and lymphocytic leukemia cell lines.