(R)-DRF053 hydrochloride hydrate

• Catalog No.: D6946
• M. F.: C23H30ClN7O2
• M. W.: 471.983
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (2R)-2-{[9-(propan-2-yl)-6-{[3-(pyridin-2-yl)phenyl]amino}-9H-purin-2-yl]amino}butan-1-ol hydrate hydrochloride
• IUPAC Traditional name: (2R)-2-[(9-isopropyl-6-{[3-(pyridin-2-yl)phenyl]amino}purin-2-yl)amino]butan-1-ol hydrate hydrochloride
• Synonyms: 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]- 9H-purin-2-yl]amino]-1-butanol hydrochloride hydrate

DATABASE IDS

• MDL Number: MFCD17215921

PROPERTIES

• Empirical Formula (Hill Notation): C23H27N7O · xHCl · yH2O
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Solubility: DMSO: ≥30 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H315-H319-H335
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 22-36/37/38
• Safety Statements: 26
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
DRF053 is a more potent version of roscovitine. It is 2 fold more potent against CDK5 (80 nM) and over 150 times more potent against CDK1 (14 nM).

Description (简体中文)

Biochem/physiol Actions
DRF053 is a more potent version of roscovitine. It is 2 fold more potent against CDK5 (80 nM) and over 150 times more potent against CDK1 (14 nM).