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Withanolide A_Molecular_structure_CAS_32911-62-9)
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Withanolide A

Catalog No. W2145 Name Sigma Aldrich
CAS Number 32911-62-9 Website http://www.sigmaaldrich.com
M. F. C28H38O6 Telephone 1-800-521-8956
M. W. 470.59772 Fax
Purity ≥95% (HPLC) Email
Storage Chembase ID: 154848

SYNONYMS

IUPAC name
(1S,2S,4S,5R,10R,11S,14S,15S,18S)-15-[(1R)-1-[(2R)-4,5-dimethyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-1-hydroxyethyl]-5-hydroxy-10,14-dimethyl-3-oxapentacyclo[9.7.0.02,4.05,10.014,18]octadec-7-en-9-one
IUPAC Traditional name
(1S,2S,4S,5R,10R,11S,14S,15S,18S)-15-[(1R)-1-[(2R)-4,5-dimethyl-6-oxo-2,3-dihydropyran-2-yl]-1-hydroxyethyl]-5-hydroxy-10,14-dimethyl-3-oxapentacyclo[9.7.0.02,4.05,10.014,18]octadec-7-en-9-one
Synonyms
(5α,6α,7α,22R)-6,7-Epoxy-5,20,22-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone

DATABASE IDS

CAS Number 32911-62-9
MDL Number MFCD07779143

PROPERTIES

Empirical Formula (Hill Notation) C28H38O6
Purity ≥95% (HPLC)
Apperance white powder
Solubility methanol: soluble1 mg/mL, clear, colorless
MSDS Link Download
Storage Temperature -20°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
C28-steroidal lactone that can induce nerve development and improve nervous system function. Potential therapeutic for neurologic disorders like Alzheimer’s and Parkinson’s disease.1 In primary rat cortical neurons, withanolide A significantly up-regulated IDE levels, a prominent enzyme involved in degrading amyloid β protein, which may help to clear excess amyloid β protein from an Alzheimer′s-inflicted brain.2
Description (简体中文)
Biochem/physiol Actions
C28-steroidal lactone that can induce nerve development and improve nervous system function. Potential therapeutic for neurologic disorders like Alzheimer’s and Parkinson’s disease.1 In primary rat cortical neurons, withanolide A significantly up-regulated IDE levels, a prominent enzyme involved in degrading amyloid β protein, which may help to clear excess amyloid β protein from an Alzheimer′s-inflicted brain.2

REFERENCES