NP603

• Catalog No.: N2290
• CAS Number: 949164-80-1
• M. F.: C26H26N2O5
• M. W.: 446.49504
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 3-(5-{[6-(3,5-dimethoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrol-3-yl)propanoic acid
• IUPAC Traditional name: 3-(5-{[6-(3,5-dimethoxyphenyl)-2-oxo-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrol-3-yl)propanoic acid
• Synonyms: 5-[[6-(3,5-Dimethoxyphenyl)-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid; (Z)-3-(5-(6-(3,5-Dimethoxyphenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrol-3-yl)-propionic acid

DATABASE IDS

• CAS Number: 949164-80-1
• MDL Number: MFCD18632551

PROPERTIES

• Empirical Formula (Hill Notation): C26H26N2O5
• Purity: ≥98% (HPLC)
• Apperance: orange-red powder
• Solubility: DMSO: ≥30 mg/mL
• GHS Hazard statements: H413
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (简体中文)

Biochem/physiol Actions
NP603 is a cell-permeable inhibitor of PDGFRβ, FGFR1 and VEGFR2 that binds to ATP pocket. NP603 is a very weak inhibitor of EGFR (IC50 >100 μM).

Description (English)

Biochem/physiol Actions
NP603 is a cell-permeable inhibitor of PDGFRβ, FGFR1 and VEGFR2 that binds to ATP pocket. NP603 is a very weak inhibitor of EGFR (IC50 >100 μM).