CI-1033

• Catalog No.: C7249
• CAS Number: 289499-45-2
• M. F.: C24H27Cl3FN5O3
• M. W.: 558.8602832
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide dihydrochloride
• IUPAC Traditional name: canertinib dihydrochloride
• Synonyms: Canertinib dihydrochloride; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride; PD183805; N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride

DATABASE IDS

• MDL Number: MFCD09954112
• CAS Number: 289499-45-2

PROPERTIES

• Empirical Formula (Hill Notation): C24H25ClFN5O3· 2HCl
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: >10 mg/mL
• Solubility: H2O: >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H315-H319-H335
• European Hazard Symbols: Irritant (Xi)
• GHS Precautionary statements: P261-P305 + P351 + P338
• Risk Statements: 36/37/38
• RTECS: UC6316110
• Safety Statements: 26
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
CI-1033 is a potent, irreversible ATP binding site-directed pan-ErbB tyrosine kinase inhibitor with IC50 in the low nanomolar range for EGFR, HER2, and ErbB-4.

Description (简体中文)

Biochem/physiol Actions
CI-1033 is a potent, irreversible ATP binding site-directed pan-ErbB tyrosine kinase inhibitor with IC50 in the low nanomolar range for EGFR, HER2, and ErbB-4.