Dihydroeponemycin

• Catalog No.: D4321
• CAS Number: 126463-64-7
• M. F.: C20H36N2O6
• M. W.: 400.50964
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-[(1S)-2-hydroxy-1-{[(2S)-1-[(2R)-2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl]carbamoyl}ethyl]-6-methylheptanamide
• IUPAC Traditional name: N-[(1S)-2-hydroxy-1-{[(2S)-1-[(2R)-2-(hydroxymethyl)oxiran-2-yl]-4-methyl-1-oxopentan-2-yl]carbamoyl}ethyl]-6-methylheptanamide

DATABASE IDS

• MDL Number: MFCD17215971
• CAS Number: 126463-64-7

PROPERTIES

• Empirical Formula (Hill Notation): C20H36N2O6
• Purity: ≥98% (HPLC)
• Apperance: off-white to light tan powder
• Optical Rotation: [α]/D ±35.7°
• Solubility: DMSO: ≥1 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• Storage Temperature: 2-8°C

DETAILS

Description (English)

Biochem/physiol Actions
Dihydroeponemycin is an active derivative of eponemycin an antitumor antibiotic isolated from Streptomyces hygroscopicus. Dihydroeponemycin labels the catalytic threonine residues of the immunoproteasome subunits LMP2 and LMP7 and the constitutive proteasome subunit X, while epoxomicin covalently modifies the N-terminal catalytic threonine residues of the constitutive proteasome (X and Z) and immunoproteasome (LMP7 and MECL1) subunits.

Description (简体中文)

Biochem/physiol Actions
Dihydroeponemycin is an active derivative of eponemycin an antitumor antibiotic isolated from Streptomyces hygroscopicus. Dihydroeponemycin labels the catalytic threonine residues of the immunoproteasome subunits LMP2 and LMP7 and the constitutive proteasome subunit X, while epoxomicin covalently modifies the N-terminal catalytic threonine residues of the constitutive proteasome (X and Z) and immunoproteasome (LMP7 and MECL1) subunits.