Penta-O-galloyl-β-D-glucose hydrate

• Catalog No.: G7548
• CAS Number: 14937-32-7(anhydrous)
• M. F.: C41H32O26
• M. W.: 940.67718
• Purity: ≥96% (HPLC)

SYNONYMS

• IUPAC name: [(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis(3,4,5-trihydroxybenzoyloxy)oxan-2-yl]methyl 3,4,5-trihydroxybenzoate
• IUPAC Traditional name: 1,2,3,4,6-pentagalloylglucose
• Synonyms: Penta-O-galloyl-beta-D-glucose; PGG; 1,2,3,4,6-pentakis(3,4,5-trihydroxybenzoate)-b-D-Glucopyranose; Penta-1,2,3,4,6-O-galloyl-b-D-glucose; 1,2,3,4,6-Penta-O-galloyl-b-D-glucopyranose; Gallic acid, pentaester with b-D-glucopyranose; Glucopyranose, pentagallate, b-D

DATABASE IDS

• MDL Number: MFCD03788860
• CAS Number: 14937-32-7(anhydrous)

PROPERTIES

• Empirical Formula (Hill Notation): C41H32O26 · xH2O
• Purity: ≥96% (HPLC)
• Apperance: light brown powder
• Solubility: DMSO: ≥20 mg/mL
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
PGG induces predominantly (caspase dependent) apoptosis in DU145 and LNCaP cells, while inducing autophagy in more resistant PC3 and TRAMP-C2 cells. It appears that PGG targeted signaling downstream of rather than the mTOR itself. Polyphenolic pyranoses were reported (J Biol Chem. 2010, 285 (11), 7892-902) to inhibit the plasminogen activator inhibitor type 1 (PAI-1).

Description (简体中文)

Biochem/physiol Actions
PGG induces predominantly (caspase dependent) apoptosis in DU145 and LNCaP cells, while inducing autophagy in more resistant PC3 and TRAMP-C2 cells. It appears that PGG targeted signaling downstream of rather than the mTOR itself. Polyphenolic pyranoses were reported (J Biol Chem. 2010, 285 (11), 7892-902) to inhibit the plasminogen activator inhibitor type 1 (PAI-1).