Copeptin trifluoroacetate human

• Catalog No.: C8749
• CAS Number: 78362-34-2(freebase)
• M. F.: C179H280F3N49O60
• M. W.: 4135.4260096
• Purity: ≥95% (HPLC)

SYNONYMS

• IUPAC name: (4S)-4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(2S)-1-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S)-2-{[(2S)-1-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-aminopropanamido]-3-hydroxypropanamido]-3-carboxypropanamido]-5-carbamimidamidopentanamido]-3-hydroxypropanamido]-3-carbamoylpropanamido]propanamido]-3-hydroxybutanamido]-4-carbamoylbutanamido]-4-methylpentanamido]-3-carboxypropanamido]acetyl}pyrrolidin-2-yl]formamido}propanamido]acetamido}propanamido]-4-methylpentanamido]-4-methylpentanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]-4-methylpentanamido]-3-methylbutanamido]-4-carbamoylbutanamido]-4-methylpentanamido]propanamido]acetamido}propanoyl]pyrrolidin-2-yl]formamido}-4-carboxybutanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-5-[(2S)-2-{[(1S)-1-{[(2S)-4-carbamoyl-1-[(2S)-2-{[(1S)-2-carboxy-1-{[(1S)-1-{[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl}ethyl]carbamoyl}ethyl]carbamoyl}pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamoyl}ethyl]carbamoyl}pyrrolidin-1-yl]-5-oxopentanoic acid; trifluoroacetic acid
• IUPAC Traditional name: (4S)-4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(2S)-1-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-{2-[(2S)-2-{[(2S)-1-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-aminopropanamido]-3-hydroxypropanamido]-3-carboxypropanamido]-5-carbamimidamidopentanamido]-3-hydroxypropanamido]-3-carbamoylpropanamido]propanamido]-3-hydroxybutanamido]-4-carbamoylbutanamido]-4-methylpentanamido]-3-carboxypropanamido]acetyl}pyrrolidin-2-yl]formamido}propanamido]acetamido}propanamido]-4-methylpentanamido]-4-methylpentanamido]-4-methylpentanamido]-5-carbamimidamidopentanamido]-4-methylpentanamido]-3-methylbutanamido]-4-carbamoylbutanamido]-4-methylpentanamido]propanamido]acetamido}propanoyl]pyrrolidin-2-yl]formamido}-4-carboxybutanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-5-[(2S)-2-{[(1S)-1-{[(2S)-4-carbamoyl-1-[(2S)-2-{[(1S)-2-carboxy-1-{[(1S)-1-{[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl}ethyl]carbamoyl}ethyl]carbamoyl}pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamoyl}ethyl]carbamoyl}pyrrolidin-1-yl]-5-oxopentanoic acid; trifluoroacetic acid
• Synonyms: H-Ala-Ser-Asp-Arg-Ser-Asn-Ala-Thr-Gln-Leu-Asp-Gly-Pro-Ala-Gly-Ala-Leu-Leu-Leu-Arg-Leu-Val-Gln-Leu-Ala-Gly-Ala-Pro-Glu-Pro-Phe-Glu-Pro-Ala-Gln-Pro-Asp-Ala-Tyr-OH trifluoroacetate

DATABASE IDS

• CAS Number: 78362-34-2(freebase)
• MDL Number: MFCD18782466

PROPERTIES

• Empirical Formula (Hill Notation): C177H279N49O58 · xC2HF3O2
• Purity: ≥95% (HPLC)
• Apperance: white to off-white powder
• Solubility: H2O: >1 mg/mL
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Copeptin, the C-terminal part of the vasopressin prohormone is a stable and sensitive surrogate marker for AVP release. Copeptin, a 39-amino acid glycopeptide that comprises the C-terminal part of the Arginine vasopressin (AVP) precursor (CT-proAVP), is cosynthesized with AVP. AVP is a primary secretagogue of the hypothalamo-pituitary-adrenal axis, a key hormone for maintaining fluid balance and vascular tone, and is a marker of acute endogenous stress. However, it has a short half-life and measurement of mature AVP is difficult and subject to errors. Copeptin in contrast is stable and easily measured.

Description (简体中文)

Biochem/physiol Actions
Copeptin, the C-terminal part of the vasopressin prohormone is a stable and sensitive surrogate marker for AVP release. Copeptin, a 39-amino acid glycopeptide that comprises the C-terminal part of the Arginine vasopressin (AVP) precursor (CT-proAVP), is cosynthesized with AVP. AVP is a primary secretagogue of the hypothalamo-pituitary-adrenal axis, a key hormone for maintaining fluid balance and vascular tone, and is a marker of acute endogenous stress. However, it has a short half-life and measurement of mature AVP is difficult and subject to errors. Copeptin in contrast is stable and easily measured.