NSC43067

• Catalog No.: N0915
• CAS Number: 26903-26-4
• M. F.: C14H12OS
• M. W.: 228.30948
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-(5-methylthiophen-2-yl)-3-phenylprop-2-en-1-one
• IUPAC Traditional name: 1-(5-methylthiophen-2-yl)-3-phenylprop-2-en-1-one
• Synonyms: NSC 43067; 1-(5-Methyl-thiophen-2-yl)-3-phenyl-propenone; 1-(5-Methyl-2-thienyl)-3-phenyl-2-Propen-1-one

DATABASE IDS

• CAS Number: 26903-26-4
• MDL Number: MFCD00489751

PROPERTIES

• Empirical Formula (Hill Notation): C14H12OS
• Purity: ≥98% (HPLC)
• Apperance: light yellow to light tan powder
• Solubility: DMSO: >20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302-H319-H413
• GHS Precautionary statements: P305 + P351 + P338
• Storage Temperature: 2-8°C

DETAILS

Description (English)

Biochem/physiol Actions
NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.

Description (简体中文)

Biochem/physiol Actions
NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.