Cardamonin

• Catalog No.: C8249
• CAS Number: 19309-14-9
• M. F.: C16H14O4
• M. W.: 270.27996
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one
• IUPAC Traditional name: cardamomin
• Synonyms: (E)-2′,4′-Dihydroxy-6′-methoxy-chalcone; (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one; (8CI); Alpinetin chalcone

DATABASE IDS

• MDL Number: MFCD00238554
• CAS Number: 19309-14-9

PROPERTIES

• Empirical Formula (Hill Notation): C16 H14 O4
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Solubility: DMSO: ≥20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H400
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273
• RID/ADR: UN 3077 9/PG 3
• Risk Statements: 50/53
• Safety Statements: 61
• Storage Temperature: room temp
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3

DETAILS

Description (English)

Biochem/physiol Actions
Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation.

Description (简体中文)

Biochem/physiol Actions
Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation.