2,5-Dimethyl-celecoxib

• Catalog No.: D7196
• CAS Number: 457639-26-8
• M. F.: C18H16F3N3O2S
• M. W.: 395.3987496
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide
• IUPAC Traditional name: 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
• Synonyms: 2,5-Dimethylcelecoxib; 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

DATABASE IDS

• MDL Number: MFCD19443858
• CAS Number: 457639-26-8

PROPERTIES

• Empirical Formula (Hill Notation): C18H16F3N3O2S
• Purity: ≥98% (HPLC)
• Apperance: off-white to light yellow powder
• Solubility: DMSO: ≥30 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P301 + P310
• Risk Statements: 25
• Safety Statements: 45
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.

Description (简体中文)

Biochem/physiol Actions
Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.