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2,5-Dimethyl-celecoxib_Molecular_structure_CAS_457639-26-8)
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2,5-Dimethyl-celecoxib

Catalog No. D7196 Name Sigma Aldrich
CAS Number 457639-26-8 Website http://www.sigmaaldrich.com
M. F. C18H16F3N3O2S Telephone 1-800-521-8956
M. W. 395.3987496 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154818

SYNONYMS

IUPAC name
4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide
IUPAC Traditional name
4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
Synonyms
2,5-Dimethylcelecoxib
4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide

DATABASE IDS

MDL Number MFCD19443858
CAS Number 457639-26-8

PROPERTIES

Empirical Formula (Hill Notation) C18H16F3N3O2S
Purity ≥98% (HPLC)
Apperance off-white to light yellow powder
Solubility DMSO: ≥30 mg/mL
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H301
European Hazard Symbols Toxic Toxic (T)
MSDS Link Download
GHS Precautionary statements P301 + P310
Risk Statements 25
Safety Statements 45
Storage Temperature room temp
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.
Description (简体中文)
Biochem/physiol Actions
Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.

REFERENCES