NS5806

• Catalog No.: N2540
• CAS Number: 426834-69-7
• M. F.: C16H8Br2F6N6O
• M. W.: 574.0727392
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 3-[3,5-bis(trifluoromethyl)phenyl]-1-[2,4-dibromo-6-(1H-1,2,3,4-tetrazol-5-yl)phenyl]urea
• IUPAC Traditional name: 3-[3,5-bis(trifluoromethyl)phenyl]-1-[2,4-dibromo-6-(1H-1,2,3,4-tetrazol-5-yl)phenyl]urea
• Synonyms: N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea

DATABASE IDS

• MDL Number: MFCD18432708
• CAS Number: 426834-69-7

PROPERTIES

• Empirical Formula (Hill Notation): C16H8Br2F6N6O
• Purity: ≥98% (HPLC)
• Apperance: white to faint yellow powder
• Solubility: DMSO: >30 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H413
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P301 + P310
• Risk Statements: 25
• Safety Statements: 45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
NS5806 increases peak current amplitude of the potassium channel Kv4.3 (EC50 = 5.3 uM). NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. In ventricular cardiomycytes, NS5806 increases transient outward current and reproduces the electrocardiographic profile of Brugada syndrome.

Description (简体中文)

Biochem/physiol Actions
NS5806 increases peak current amplitude of the potassium channel Kv4.3 (EC50 = 5.3 uM). NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. In ventricular cardiomycytes, NS5806 increases transient outward current and reproduces the electrocardiographic profile of Brugada syndrome.