N-acetylcysteine amide

• Catalog No.: A0737
• CAS Number: 38520-57-9
• M. F.: C5H10N2O2S
• M. W.: 162.2101
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: (2R)-2-acetamido-3-sulfanylpropanamide
• IUPAC Traditional name: (2R)-2-acetamido-3-sulfanylpropanamide
• Synonyms: N-Acetyl-L-cysteinamide; NACA; AD4; (R)- 2-(Acetylamino)-3-mercapto-Propanamide; acetylcysteinamide

DATABASE IDS

• MDL Number: MFCD01696115
• CAS Number: 38520-57-9

PROPERTIES

• Empirical Formula (Hill Notation): C5H10N2O2S
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: H2O: ≥20 mg/mL
• Solubility: DMSO: >40 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Other Notes
This product is hydroscopic and air sensitive.
Biochem/physiol Actions
N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders.

Description (简体中文)

Other Notes
This product is hydroscopic and air sensitive.
Biochem/physiol Actions
N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders.