VU0238429

• Catalog No.: V4515
• CAS Number: 1160247-92-6
• M. F.: C17H12F3NO4
• M. W.: 351.2766896
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-2,3-dihydro-1H-indole-2,3-dione
• IUPAC Traditional name: 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione
• Synonyms: 1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione

DATABASE IDS

• MDL Number: MFCD16618396
• CAS Number: 1160247-92-6

PROPERTIES

• Empirical Formula (Hill Notation): C17H12F3NO4
• Purity: ≥98% (HPLC)
• Apperance: orange powder
• Solubility: DMSO: ≥20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H319-H400
• European Hazard Symbols: Irritant (Xi)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P305 + P351 + P338
• Risk Statements: 36-50/53
• Safety Statements: 26-60-61
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. M5 is thought to regulate cerebral blood flow, and activation of M5 may be therapeutic for Alzheimer′s disease. VU0238429 is the first reported M5-selective small molecule of any kind. It is >30-fold more selective for M5 over M1, M2, M3, and M4.

Description (简体中文)

Biochem/physiol Actions
VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. M5 is thought to regulate cerebral blood flow, and activation of M5 may be therapeutic for Alzheimer′s disease. VU0238429 is the first reported M5-selective small molecule of any kind. It is >30-fold more selective for M5 over M1, M2, M3, and M4.