Meptazinol hydrochloride

• Catalog No.: M2824
• CAS Number: 59263-76-2
• M. F.: C15H24ClNO
• M. W.: 269.81016
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 3-(3-ethyl-1-methylazepan-3-yl)phenol hydrochloride
• IUPAC Traditional name: meptazinol hydrochloride
• Synonyms: WY-22811 hydrochloride; IL-22811 hydrochloride; 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-phenol hydrochloride

DATABASE IDS

• CAS Number: 59263-76-2
• MDL Number: MFCD00941476
• EC Number: 261-683-0

PROPERTIES

• Empirical Formula (Hill Notation): C15H23NO· HCl
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: H2O: >10 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• RTECS: SL4250000
• German water hazard class: 1

DETAILS

Description (English)

Biochem/physiol Actions
Meptazinol entered the human pharmaceutical market as a racemic mixture in the 1980s for use as an analgesic. Its pharmacology is not completely understood; however, its analgesic properties are mostly due to its partial agonism at the mu1 opioid receptor. Due to its partial agonism, Meptazinol antagonizes morphine dependence in vivo. Its advantage over other opiates is its reduced capacity to cause addition and respiratory depression, also due to its intrinsic activity as a partial agonist. Meptazinol has been found to have additional activity as an acetylcholinesterase (AChE) inhibitor, particularly in its (-) enantiomeric form, which may partially explain its analgesic properties. AChE inhibitors are used to treat Alzheimer′s disease, providing additional interest in this compound.

Description (简体中文)

Biochem/physiol Actions
Meptazinol entered the human pharmaceutical market as a racemic mixture in the 1980s for use as an analgesic. Its pharmacology is not completely understood; however, its analgesic properties are mostly due to its partial agonism at the mu1 opioid receptor. Due to its partial agonism, Meptazinol antagonizes morphine dependence in vivo. Its advantage over other opiates is its reduced capacity to cause addition and respiratory depression, also due to its intrinsic activity as a partial agonist. Meptazinol has been found to have additional activity as an acetylcholinesterase (AChE) inhibitor, particularly in its (-) enantiomeric form, which may partially explain its analgesic properties. AChE inhibitors are used to treat Alzheimer′s disease, providing additional interest in this compound.