DMH4

• Catalog No.: D8696
• CAS Number: 515880-75-8
• M. F.: C24H24N4O2
• M. W.: 400.47296
• Purity: >99.0% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 4-[2-(4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}phenoxy)ethyl]morpholine
• IUPAC Traditional name: 4-[2-(4-{3-phenylpyrazolo[1,5-a]pyrimidin-6-yl}phenoxy)ethyl]morpholine

DATABASE IDS

• CAS Number: 515880-75-8
• MDL Number: MFCD18452839

PROPERTIES

• Empirical Formula (Hill Notation): C24H24 N4O2
• Purity: >99.0% (HPLC)
• Apperance: off-white to brown powder
• Solubility: DMSO: soluble20 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
DMH4 is a potent VEGF inhibitor and an angiogenesis inhbitor. It is a selective VEGF inhibitor with an IC50 of 161 nM for VEGFR inhibition compared to 8000 nM for AMPK. Unlike the structurally similar DMH1, which is a selective BMP inhibitor, DMH4 shows little affinitiy for BMP with an IC50 of 3500 nM for BMPR-I.

Description (简体中文)

Biochem/physiol Actions
DMH4 is a potent VEGF inhibitor and an angiogenesis inhbitor. It is a selective VEGF inhibitor with an IC50 of 161 nM for VEGFR inhibition compared to 8000 nM for AMPK. Unlike the structurally similar DMH1, which is a selective BMP inhibitor, DMH4 shows little affinitiy for BMP with an IC50 of 3500 nM for BMPR-I.