Atovaquone

• Catalog No.: A7986
• CAS Number: 95233-18-4
• M. F.: C22H19ClO3
• M. W.: 366.83746
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-hydroxy-3-[(1r,4r)-4-(4-chlorophenyl)cyclohexyl]-1,4-dihydronaphthalene-1,4-dione
• IUPAC Traditional name: atovaquone
• Synonyms: trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione; Mepron

DATABASE IDS

• CAS Number: 95233-18-4

PROPERTIES

• Empirical Formula (Hill Notation): C22H19ClO3
• Purity: ≥98% (HPLC)
• Apperance: yellow powder
• Solubility: DMSO: >10 mg/mL
• European Hazard Symbols: Nature polluting (N)
• Risk Statements: 50/53
• RTECS: QJ5616500
• Safety Statements: 60-61
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Application
Atovaquone inhibits the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket. In addition to its use as a treatment for toxoplasmosis, atovaquone has antimalarial properties and prevents pneumocystis pneumonia post-renal transplant.
Biochem/physiol Actions
Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It is an analog of protozoan mitochondrial protein ubiquinone, and acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket.

Description (简体中文)

Application
Atovaquone inhibits the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket. In addition to its use as a treatment for toxoplasmosis, atovaquone has antimalarial properties and prevents pneumocystis pneumonia post-renal transplant.
Biochem/physiol Actions
Atovaquone is an anti-protozoal mitochondrial electron transport inhibitor; Antimalarial; Antipneumocystic, and has also been used to treat toxoplasmosis. It is an analog of protozoan mitochondrial protein ubiquinone, and acts by inhibiting the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket.