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3′,4′-Dimethoxyflavone_Molecular_structure_CAS_4143-62-8)
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3′,4′-Dimethoxyflavone

Catalog No. D6571 Name Sigma Aldrich
CAS Number 4143-62-8 Website http://www.sigmaaldrich.com
M. F. C17H14O4 Telephone 1-800-521-8956
M. W. 282.29066 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154775

SYNONYMS

IUPAC name
2-(3,4-dimethoxyphenyl)-4H-chromen-4-one
IUPAC Traditional name
2-(3,4-dimethoxyphenyl)chromen-4-one
Synonyms
2-(3,4-Dimethoxyphenyl)chromen-4-one
3′,4′-DMF

DATABASE IDS

MDL Number MFCD00143009
CAS Number 4143-62-8

PROPERTIES

Empirical Formula (Hill Notation) C17H14O4
Purity ≥98% (HPLC)
Apperance white to off-white powder
Solubility DMSO: ≥20 mg/mL
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H301
European Hazard Symbols Toxic Toxic (T)
MSDS Link Download
GHS Precautionary statements P301 + P310
Risk Statements 25
Safety Statements 45
Storage Temperature room temp
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
3′,4′-dimethoxyflavone is a competitive antagonist of the AhR that inhibits AhR-mediated induction of CYP1A1, and also displays antiestrogen activity in breast tumor cell lines. The compound blocks transformation of the cytosolic AhR complex, and formation of nuclear AhR complexes.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D6571.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Description (简体中文)
Biochem/physiol Actions
3′,4′-dimethoxyflavone is a competitive antagonist of the AhR that inhibits AhR-mediated induction of CYP1A1, and also displays antiestrogen activity in breast tumor cell lines. The compound blocks transformation of the cytosolic AhR complex, and formation of nuclear AhR complexes.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D6571.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

REFERENCES