RG-239 hydrate

• Catalog No.: R0783
• M. F.: C33H54O4
• M. W.: 514.77946
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (1R,2R,5S,8R,9R,10R,13R,14R,17R,19R)-17-hydroxy-1,2,14,18,18-pentamethyl-8-(prop-1-en-2-yl)-17-(prop-2-en-1-yl)pentacyclo[11.8.0.0^2,^1^0.0^5,^9.0^1^4,^1^9]henicosane-5-carboxylic acid hydrate
• IUPAC Traditional name: (1R,2R,5S,8R,9R,10R,13R,14R,17R,19R)-17-hydroxy-1,2,14,18,18-pentamethyl-8-(prop-1-en-2-yl)-17-(prop-2-en-1-yl)pentacyclo[11.8.0.0^2,^1^0.0^5,^9.0^1^4,^1^9]henicosane-5-carboxylic acid hydrate
• Synonyms: 18 dia 2; (3R)-3-Allyl-3-hydroxylup-20(29)-en-28-oic acid hydrate; (3?)-3-Hydroxy-3-(2-propen-1-yl)-lup-20(29)-en-28-oic acid hydrate

DATABASE IDS

• MDL Number: MFCD17215967

PROPERTIES

• Empirical Formula (Hill Notation): C33H52O3 · xH2O
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: ≥10 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P301 + P310
• Risk Statements: 22
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
RG-239 is a TGR5 agonist
Semisynthetic derivative of betulinic acid (3β-allylbetulinic acid), RG-239 is an agonist at the G-protein coupled receptor TGR5. TGR5 signalling induces glucagon-like peptide-1 (GLP-1) release in brown adipose tissue, enhancing glucose tolerance and attenuating diet-induced obesity.

Description (简体中文)

Biochem/physiol Actions
RG-239 is a TGR5 agonist
Semisynthetic derivative of betulinic acid (3β-allylbetulinic acid), RG-239 is an agonist at the G-protein coupled receptor TGR5. TGR5 signalling induces glucagon-like peptide-1 (GLP-1) release in brown adipose tissue, enhancing glucose tolerance and attenuating diet-induced obesity.