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Frondoside A hydrate_Molecular_structure_CAS_127367-76-4(anhydrous))
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Frondoside A hydrate

Catalog No. F0808 Name Sigma Aldrich
CAS Number 127367-76-4(anhydrous) Website http://www.sigmaaldrich.com
M. F. C60H95NaO29S Telephone 1-800-521-8956
M. W. 1335.43367 Fax
Purity ≥96% (HPLC) Email
Storage desiccated Chembase ID: 154767

SYNONYMS

IUPAC name
sodium 6-{[(2S,4S,5R,6S,13R,16S,18R)-4-(acetyloxy)-2,6,13,17,17-pentamethyl-6-(4-methylpentyl)-8-oxo-7-oxapentacyclo[10.8.0.02,9.05,9.013,18]icos-1(20)-en-16-yl]oxy}-5-({5-[(4-{[3,5-dihydroxy-6-(hydroxymethyl)-4-methoxyoxan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl)oxy]-4-hydroxy-6-methyl-3-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxan-2-yl}oxy)-4-hydroxyoxan-3-yl sulfate
IUPAC Traditional name
sodium 6-{[(2S,4S,5R,6S,13R,16S,18R)-4-(acetyloxy)-2,6,13,17,17-pentamethyl-6-(4-methylpentyl)-8-oxo-7-oxapentacyclo[10.8.0.02,9.05,9.013,18]icos-1(20)-en-16-yl]oxy}-5-({5-[(4-{[3,5-dihydroxy-6-(hydroxymethyl)-4-methoxyoxan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl)oxy]-4-hydroxy-6-methyl-3-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxan-2-yl}oxy)-4-hydroxyoxan-3-yl sulfate

DATABASE IDS

CAS Number 127367-76-4(anhydrous)

PROPERTIES

Empirical Formula (Hill Notation) C60H95O29S·Na · xH2O
Purity ≥96% (HPLC)
Apperance white to off-white powder
Solubility H2O: ≥10 mg/mL
MSDS Link Download
Storage Condition desiccated
Storage Temperature -20°C
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Frondoside A is a bioactive triterpenoid saponin from sea cucumber; and an immunostimulant. Frondoside A is an extremely potent inducer of apoptosis, and although it does activate caspaces, it can induce apoptosis in HL-60 cells through a mechanism distinct from extrinsic and intrinsic apoptosis pathways. It potentially valuable for cancers that are resistent to other apoptosis inducers, such as pancreatic cancer.
Description (简体中文)
Biochem/physiol Actions
Frondoside A is a bioactive triterpenoid saponin from sea cucumber; and an immunostimulant. Frondoside A is an extremely potent inducer of apoptosis, and although it does activate caspaces, it can induce apoptosis in HL-60 cells through a mechanism distinct from extrinsic and intrinsic apoptosis pathways. It potentially valuable for cancers that are resistent to other apoptosis inducers, such as pancreatic cancer.

REFERENCES