Frondoside A hydrate

• Catalog No.: F0808
• CAS Number: 127367-76-4(anhydrous)
• M. F.: C60H95NaO29S
• M. W.: 1335.43367
• Purity: ≥96% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: sodium 6-{[(2S,4S,5R,6S,13R,16S,18R)-4-(acetyloxy)-2,6,13,17,17-pentamethyl-6-(4-methylpentyl)-8-oxo-7-oxapentacyclo[10.8.0.0^2,^9.0^5,^9.0^1^3,^1^8]icos-1(20)-en-16-yl]oxy}-5-({5-[(4-{[3,5-dihydroxy-6-(hydroxymethyl)-4-methoxyoxan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl)oxy]-4-hydroxy-6-methyl-3-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxan-2-yl}oxy)-4-hydroxyoxan-3-yl sulfate
• IUPAC Traditional name: sodium 6-{[(2S,4S,5R,6S,13R,16S,18R)-4-(acetyloxy)-2,6,13,17,17-pentamethyl-6-(4-methylpentyl)-8-oxo-7-oxapentacyclo[10.8.0.0^2,^9.0^5,^9.0^1^3,^1^8]icos-1(20)-en-16-yl]oxy}-5-({5-[(4-{[3,5-dihydroxy-6-(hydroxymethyl)-4-methoxyoxan-2-yl]oxy}-3,5-dihydroxyoxan-2-yl)oxy]-4-hydroxy-6-methyl-3-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxan-2-yl}oxy)-4-hydroxyoxan-3-yl sulfate

DATABASE IDS

• CAS Number: 127367-76-4(anhydrous)

PROPERTIES

• Empirical Formula (Hill Notation): C60H95O29S·Na · xH2O
• Purity: ≥96% (HPLC)
• Apperance: white to off-white powder
• Solubility: H2O: ≥10 mg/mL
• Storage Condition: desiccated
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Frondoside A is a bioactive triterpenoid saponin from sea cucumber; and an immunostimulant. Frondoside A is an extremely potent inducer of apoptosis, and although it does activate caspaces, it can induce apoptosis in HL-60 cells through a mechanism distinct from extrinsic and intrinsic apoptosis pathways. It potentially valuable for cancers that are resistent to other apoptosis inducers, such as pancreatic cancer.

Description (简体中文)

Biochem/physiol Actions
Frondoside A is a bioactive triterpenoid saponin from sea cucumber; and an immunostimulant. Frondoside A is an extremely potent inducer of apoptosis, and although it does activate caspaces, it can induce apoptosis in HL-60 cells through a mechanism distinct from extrinsic and intrinsic apoptosis pathways. It potentially valuable for cancers that are resistent to other apoptosis inducers, such as pancreatic cancer.