JK184

• Catalog No.: J4205
• CAS Number: 315703-52-7
• M. F.: C20H19N3OS
• M. W.: 349.44936
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-[(4-ethoxyphenyl)methyl]-4-{2-methylimidazo[1,2-a]pyridin-3-yl}-1,3-thiazole
• IUPAC Traditional name: 2-[(4-ethoxyphenyl)methyl]-4-{2-methylimidazo[1,2-a]pyridin-3-yl}-1,3-thiazole
• Synonyms: N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

DATABASE IDS

• CAS Number: 315703-52-7

PROPERTIES

• Empirical Formula (Hill Notation): C19H18N4OS
• Purity: ≥98% (HPLC)
• Apperance: off-white to light brown powder
• Solubility: DMSO: ≥20 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H302-H318
• European Hazard Symbols: Harmful (Xn)
• GHS Precautionary statements: P280-P305 + P351 + P338
• Risk Statements: 22-41
• Safety Statements: 26-36
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
JK184 is a Hedgehog signaling pathway antagonist. JK184 blocks sonic hedgehog induced Gli transcription with an IC50 of 30 nM, and disrupts hedgehog signalling by inhibition of alcohol dehydrogenase 7 and depolymerization of mirotubules.

Description (简体中文)

Biochem/physiol Actions
JK184 is a Hedgehog signaling pathway antagonist. JK184 blocks sonic hedgehog induced Gli transcription with an IC50 of 30 nM, and disrupts hedgehog signalling by inhibition of alcohol dehydrogenase 7 and depolymerization of mirotubules.