n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate

• Catalog No.: A0987
• M. F.: C22H34O5
• M. W.: 378.50236
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: pentyl 2-(3,5-dihydroxy-2-nonanoylphenyl)acetate
• IUPAC Traditional name: pentyl 2-(3,5-dihydroxy-2-nonanoylphenyl)acetate
• Synonyms: Cytosporone A n-amyl ester; compound 10i

DATABASE IDS

• MDL Number: MFCD18632550

PROPERTIES

• Empirical Formula (Hill Notation): C22H34O5
• Purity: ≥98% (HPLC)
• Apperance: white powder
• Solubility: DMSO: >65 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate is a Nur77 agonist. Nur77 is a steroid orphan receptor that plays a critical role in regulating proliferation, differentiation and apoptosis. n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate, a cytosporone B analog, is a stronger activator of Nur77 than it parent compound. n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate treatment causes Nur77 migration to mitochondria, which results in mitochondrial Cyt c release into the cytoplasm and mitochondrial AIF redistribution in both the cytoplasm and nucleus.

Description (简体中文)

Biochem/physiol Actions
n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate is a Nur77 agonist. Nur77 is a steroid orphan receptor that plays a critical role in regulating proliferation, differentiation and apoptosis. n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate, a cytosporone B analog, is a stronger activator of Nur77 than it parent compound. n-Amyl 2-[3,5-dihydroxy-2-(1-nonanoyl)phenyl]acetate treatment causes Nur77 migration to mitochondria, which results in mitochondrial Cyt c release into the cytoplasm and mitochondrial AIF redistribution in both the cytoplasm and nucleus.