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PF-4708671_Molecular_structure_CAS_1255517-76-0)
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PF-4708671

Catalog No. PZ0143 Name Sigma Aldrich
CAS Number 1255517-76-0 Website http://www.sigmaaldrich.com
M. F. C19H21F3N6 Telephone 1-800-521-8956
M. W. 390.4054496 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154750

SYNONYMS

IUPAC name
2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-1,3-benzodiazole
IUPAC Traditional name
2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-1,3-benzodiazole
Synonyms
2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

DATABASE IDS

MDL Number MFCD18086922
CAS Number 1255517-76-0

PROPERTIES

Empirical Formula (Hill Notation) C19H21F3N6
Purity ≥98% (HPLC)
Gene Information human ... RPS6KB1(6198)mouse ... Rps6kb1(72508)rat ... Rps6kb1(83840)
Apperance off-white powder
Solubility DMSO: ≥20 mg/mL
GHS Pictograms GHS06
GHS Signal Word Danger
GHS Hazard statements H301
European Hazard Symbols Toxic Toxic (T)
MSDS Link Download
GHS Precautionary statements P301 + P310
Risk Statements 25
Safety Statements 45
Storage Temperature room temp
German water hazard class 3

DETAILS

Description (English)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor. PF-4708671 inhibits S6K1 with a Ki of 20 nM and IC50 of 160 nM, while having no effect on the closely related RSK and MSK kinases.
Description (简体中文)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor. PF-4708671 inhibits S6K1 with a Ki of 20 nM and IC50 of 160 nM, while having no effect on the closely related RSK and MSK kinases.

REFERENCES