Naftifine hydrochloride

• Catalog No.: N1790
• CAS Number: 65473-14-5
• M. F.: C21H22ClN
• M. W.: 323.85908
• Purity: ≥99%

SYNONYMS

• IUPAC name: methyl(naphthalen-1-ylmethyl)(3-phenylprop-2-en-1-yl)amine hydrochloride
• IUPAC Traditional name: naftin hydrochloride

DATABASE IDS

• CAS Number: 65473-14-5
• MDL Number: MFCD00059047

PROPERTIES

• Empirical Formula (Hill Notation): C21H21N · HCl
• Purity: ≥99%
• Storage Temperature: 2-8°C
• German water hazard class: nwg

DETAILS

Description (English)

Biochem/physiol Actions
Allylamine compound that has antifungal and antimycotic activities.3 Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis.4 Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria2 and has demonstrated anti-inflammatory properties.5
Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion2. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells1.
Application
Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis1.

Description (简体中文)

Biochem/physiol Actions
Allylamine compound that has antifungal and antimycotic activities.3 Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis.4 Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria2 and has demonstrated anti-inflammatory properties.5
Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion2. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells1.
Application
Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis1.