PS48

• Catalog No.: P0022
• CAS Number: 1180676-32-7
• M. F.: C17H15ClO2
• M. W.: 286.7528
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: 5-(4-chlorophenyl)-3-phenylpent-2-enoic acid
• IUPAC Traditional name: 5-(4-chlorophenyl)-3-phenylpent-2-enoic acid
• Synonyms: 5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid

DATABASE IDS

• MDL Number: MFCD17215962
• CAS Number: 1180676-32-7

PROPERTIES

• Empirical Formula (Hill Notation): C17H15ClO2
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: >20 mg/mL
• RID/ADR: UN 3077 9/PG 3
• Storage Condition: protect from light
• Storage Temperature: 2-8°C
• Hazard Class: 9
• UN Number: 3077
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.

Description (简体中文)

Biochem/physiol Actions
PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.