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(E/Z)-BCI hydrochloride_Molecular_structure_CAS_95130-23-7)
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(E/Z)-BCI hydrochloride

Catalog No. B4313 Name Sigma Aldrich
CAS Number 95130-23-7 Website http://www.sigmaaldrich.com
M. F. C22H24ClNO Telephone 1-800-521-8956
M. W. 353.88506 Fax
Purity ≥98% (HPLC) Email
Storage desiccated Chembase ID: 154743

SYNONYMS

IUPAC name
3-(cyclohexylamino)-2-(phenylmethylidene)-2,3-dihydro-1H-inden-1-one hydrochloride
IUPAC Traditional name
3-(cyclohexylamino)-2-(phenylmethylidene)-3H-inden-1-one hydrochloride
Synonyms
NSC 150117 hydrochloride
(E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one; 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1Hinden-1-one; 2-benzylidene-3-(cyclohexylamino)-1-Indanone hydrochloride

DATABASE IDS

MDL Number MFCD16875416
CAS Number 95130-23-7

PROPERTIES

Empirical Formula (Hill Notation) C22H23NO · HCl
Purity ≥98% (HPLC)
Apperance yellow powder
Solubility DMSO: ≥10 mg/mL
MSDS Link Download
RID/ADR UN 3077 9/PG 3
Storage Condition desiccated
Storage Temperature 2-8°C
Hazard Class 9
UN Number 3077
Packing Group 3
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
BCI is an allosteric inhibitor of Dusp6 that acts within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also hyperactivates FGF signaling, since Dusp6 functions as a feedback regulator of FGF signaling.
Description (简体中文)
Biochem/physiol Actions
BCI is an allosteric inhibitor of Dusp6 that acts within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also hyperactivates FGF signaling, since Dusp6 functions as a feedback regulator of FGF signaling.

REFERENCES