Proguanil hydrochloride

• Catalog No.: G7048
• CAS Number: 637-32-1
• M. F.: C11H17Cl2N5
• M. W.: 290.19218
• Purity: ≥95% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 1-3-(4-chlorophenyl)carbamimidamido-N-(propan-2-yl)methanimidamide hydrochloride
• IUPAC Traditional name: proguanil hydrochloride
• Synonyms: N1-(4-Chlorophenyl)-N5-isopropylbiguanide; Chlorguanide

DATABASE IDS

• CAS Number: 637-32-1
• EC Number: 211-283-7
• MDL Number: MFCD01732193

PROPERTIES

• Empirical Formula (Hill Notation): C11H16ClN5·HCl
• Purity: ≥95% (HPLC)
• Apperance: solid
• Solubility: acetonitrile: water: ~1 mg/mL (60/40)
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25
• RTECS: DU1750000
• Safety Statements: 45
• Storage Condition: desiccated
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain.1 Mutations in DHFR account for the development of resistant strains.2

Description (简体中文)

Biochem/physiol Actions
Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain.1 Mutations in DHFR account for the development of resistant strains.2