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CP-802079 hydrochloride hydrate_Molecular_structure_CAS_736175-49-8(freebase))
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CP-802079 hydrochloride hydrate

Catalog No. PZ0148 Name Sigma Aldrich
CAS Number 736175-49-8(freebase) Website http://www.sigmaaldrich.com
M. F. C22H24Cl2N2O5S Telephone 1-800-521-8956
M. W. 499.40736 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154734

SYNONYMS

IUPAC name
2-{[3-(4-chlorophenyl)-3-[4-(1,3-thiazole-2-carbonyl)phenoxy]propyl](methyl)amino}acetic acid hydrate hydrochloride
IUPAC Traditional name
{[3-(4-chlorophenyl)-3-[4-(1,3-thiazole-2-carbonyl)phenoxy]propyl](methyl)amino}acetic acid hydrate hydrochloride
Synonyms
N-[3-(4-Chlorophenyl)-3-[4-(2-thiazolylcarbonyl)phenoxy]propyl]-N-methyl-glycine hydrochloride hydrate
({3-(4-Chlorophenyl)-3-[4-(thiazole-carbonyl)-phenoxy]-propyl}-methyl-amino)-acetic acid hydrochloride hydrate

DATABASE IDS

MDL Number MFCD18452850
CAS Number 736175-49-8(freebase)

PROPERTIES

Empirical Formula (Hill Notation) C22H21ClN2O4S · xHCl · yH2O
Purity ≥98% (HPLC)
Apperance very light brown powder
Solubility DMSO: ≥20 mg/mL
GHS Pictograms GHS07
GHS Signal Word Warning
GHS Hazard statements H302-H315-H319-H335
European Hazard Symbols Harmful Harmful (Xn)
MSDS Link Download
GHS Precautionary statements P261-P305 + P351 + P338
Risk Statements 22-36/37/38
Safety Statements 26
Storage Temperature 2-8°C
German water hazard class 3

DETAILS

Description (English)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
CP-802079 is a potent and selective glycine transporter type 1 (GlyT1) antagonist. Antagonists of GlyT1 increase levels of glycine in the synaptic cleft and, like direct glycine site agonists, they can augment NMDAR currents and NMDAR-mediated functions. CP-802,079 significantly increases the amplitude of the NMDAR currents and LTP.
Description (简体中文)
Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
CP-802079 is a potent and selective glycine transporter type 1 (GlyT1) antagonist. Antagonists of GlyT1 increase levels of glycine in the synaptic cleft and, like direct glycine site agonists, they can augment NMDAR currents and NMDAR-mediated functions. CP-802,079 significantly increases the amplitude of the NMDAR currents and LTP.

REFERENCES