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Olopatadine hydrochloride_Molecular_structure_CAS_140462-76-6)
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Olopatadine hydrochloride

Catalog No. O0391 Name Sigma Aldrich
CAS Number 140462-76-6 Website http://www.sigmaaldrich.com
M. F. C21H24ClNO3 Telephone 1-800-521-8956
M. W. 373.87316 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154726

SYNONYMS

IUPAC name
2-{2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaen-5-yl}acetic acid hydrochloride
IUPAC Traditional name
{2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaen-5-yl}acetic acid hydrochloride
Synonyms
(11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride
AL-4943A
KW-4679
Opatanol
Patanol

DATABASE IDS

CAS Number 140462-76-6
MDL Number MFCD00875716

PROPERTIES

Empirical Formula (Hill Notation) C21H23NO3·HCl
Purity ≥98% (HPLC)
Apperance solid
Solubility H2O: ≥20 mg/mL
GHS Pictograms GHS06
GHS Pictograms GHS09
GHS Signal Word Danger
GHS Hazard statements H301-H400
European Hazard Symbols Toxic Toxic (T)
European Hazard Symbols Nature polluting Nature polluting (N)
MSDS Link Download
GHS Precautionary statements P273-P301 + P310
RID/ADR UN 2811 6.1/PG 3
Risk Statements 25-50
Safety Statements 45-61
Storage Temperature room temp
Hazard Class 6.1
UN Number 2811
Packing Group 3
German water hazard class 3

DETAILS

Description (English)
Biochem/physiol Actions
Olopatadine is a histamine H1 receptor antagonist and mast cell stabilizer. The low level of occupancy H1 receptors in the brain explains the low sedation effect of olopatidine. It is believed that olopatidine is a substrate for P-glycoprotein, which limits its brain penetration.1
Description (简体中文)
Biochem/physiol Actions
Olopatadine is a histamine H1 receptor antagonist and mast cell stabilizer. The low level of occupancy H1 receptors in the brain explains the low sedation effect of olopatidine. It is believed that olopatidine is a substrate for P-glycoprotein, which limits its brain penetration.1

REFERENCES