Olopatadine hydrochloride

• Catalog No.: O0391
• CAS Number: 140462-76-6
• M. F.: C21H24ClNO3
• M. W.: 373.87316
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-{2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^3,^8]pentadeca-1(15),3(8),4,6,11,13-hexaen-5-yl}acetic acid hydrochloride
• IUPAC Traditional name: {2-[3-(dimethylamino)propylidene]-9-oxatricyclo[9.4.0.0^3,^8]pentadeca-1(15),3(8),4,6,11,13-hexaen-5-yl}acetic acid hydrochloride
• Synonyms: (11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride; AL-4943A; KW-4679; Opatanol; Patanol

DATABASE IDS

• CAS Number: 140462-76-6
• MDL Number: MFCD00875716

PROPERTIES

• Empirical Formula (Hill Notation): C21H23NO3·HCl
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: H2O: ≥20 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H400
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25-50
• Safety Statements: 45-61
• Storage Temperature: room temp
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Olopatadine is a histamine H1 receptor antagonist and mast cell stabilizer. The low level of occupancy H1 receptors in the brain explains the low sedation effect of olopatidine. It is believed that olopatidine is a substrate for P-glycoprotein, which limits its brain penetration.1

Description (简体中文)

Biochem/physiol Actions
Olopatadine is a histamine H1 receptor antagonist and mast cell stabilizer. The low level of occupancy H1 receptors in the brain explains the low sedation effect of olopatidine. It is believed that olopatidine is a substrate for P-glycoprotein, which limits its brain penetration.1