SJ-172550

• Catalog No.: S7451
• CAS Number: 431979-47-4
• M. F.: C22H21ClN2O5
• M. W.: 428.86554
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: methyl 2-{2-chloro-6-ethoxy-4-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-ylidene)methyl]phenoxy}acetate
• IUPAC Traditional name: methyl 2-{2-chloro-6-ethoxy-4-[(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]phenoxy}acetate
• Synonyms: 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-acetic acid methyl ester

DATABASE IDS

• CAS Number: 431979-47-4
• MDL Number: MFCD03142926

PROPERTIES

• Empirical Formula (Hill Notation): C22H21N2O5Cl
• Purity: ≥98% (HPLC)
• Apperance: orange powder
• Solubility: DMSO: ≥30 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
SJ-17255 is a MDMX inhibitor. Similarly to MDM2, MDMX regulates p53. But in contrast to MDM2, MDMX appears to directly regulate p53 transcription. SJ-172550 is a first small-molecule inhibitor of MDMX with a low micromolar binding constant. It appears that SJ-172550 is binding to the p53-binding pocket of MDMX, thus liberating p53 to induce apoptosis.

Description (简体中文)

Biochem/physiol Actions
SJ-17255 is a MDMX inhibitor. Similarly to MDM2, MDMX regulates p53. But in contrast to MDM2, MDMX appears to directly regulate p53 transcription. SJ-172550 is a first small-molecule inhibitor of MDMX with a low micromolar binding constant. It appears that SJ-172550 is binding to the p53-binding pocket of MDMX, thus liberating p53 to induce apoptosis.