FM19G11

• Catalog No.: F8807
• CAS Number: 329932-55-0
• M. F.: C23H17N3O8
• M. W.: 463.39638
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: 2-(4-methylphenyl)-2-oxoethyl 3-(2,4-dinitrobenzamido)benzoate
• IUPAC Traditional name: 2-(4-methylphenyl)-2-oxoethyl 3-(2,4-dinitrobenzamido)benzoate
• Synonyms: [2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate; 3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester

DATABASE IDS

• CAS Number: 329932-55-0
• MDL Number: MFCD01174289

PROPERTIES

• Empirical Formula (Hill Notation): C23H17N3O8
• Purity: ≥98% (HPLC)
• Apperance: off-white to light brown powder
• Solubility: DMSO: ≥40 mg/mL
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.

Description (简体中文)

Biochem/physiol Actions
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.