FR-900098 monosodium salt

• Catalog No.: F8307
• CAS Number: 73226-73-0
• M. F.: C5H11NNaO5P
• M. W.: 219.108071
• Purity: ≥97% (NMR)
• Storage: desiccated

SYNONYMS

• IUPAC name: sodium hydrogen [3-(N-hydroxyacetamido)propyl]phosphonate
• IUPAC Traditional name: sodium hydrogen 3-(N-hydroxyacetamido)propylphosphonate
• Synonyms: BRN 2096083; P-[3-(Acetylhydroxyamino)propyl]-phosphonic acid; (3-(Acetylhydroxyamino)propyl)-phosphonic acid

DATABASE IDS

• MDL Number: MFCD17215926
• CAS Number: 73226-73-0

PROPERTIES

• Empirical Formula (Hill Notation): C5H11NNaO5P
• Purity: ≥97% (NMR)
• Apperance: yellow to orange powder
• Solubility: H2O: ≥20 mg/mL
• Storage Condition: desiccated
• Storage Condition: protect from light
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway). Inhibiton of the enzyme provides alternative to traditional antimalaria therapy. FR-900098 is twice more effective than fosmidomycin against various strains of P. falciparum in vitro and the closely related P. vinckei in mice.

Description (简体中文)

Biochem/physiol Actions
1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway). Inhibiton of the enzyme provides alternative to traditional antimalaria therapy. FR-900098 is twice more effective than fosmidomycin against various strains of P. falciparum in vitro and the closely related P. vinckei in mice.