PD 0325901

• Catalog No.: PZ0162
• CAS Number: 391210-10-9
• M. F.: C16H14F3IN2O4
• M. W.: 482.1930396
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
• IUPAC Traditional name: N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
• Synonyms: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide

DATABASE IDS

• MDL Number: MFCD08435926
• CAS Number: 391210-10-9

PROPERTIES

• Empirical Formula (Hill Notation): C16H14F3IN2O4
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Optical Rotation: [α]/D -1.8 to -3.0°, c = 1 mg/mL in methanol
• Solubility: DMSO: ≥20 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301-H373-H410
• European Hazard Symbols: Toxic (T)
• European Hazard Symbols: Nature polluting (N)
• GHS Precautionary statements: P273-P301 + P310-P501
• Risk Statements: 25-48-50
• Safety Statements: 22-36/37/39-61
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.

Description (简体中文)

Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.