Myxothiazol

• Catalog No.: T5580
• CAS Number: 76706-55-3
• M. F.: C25H33N3O3S2
• M. W.: 487.67782
• Purity: ≥98% (HPLC)
• Storage: protect from light

SYNONYMS

• IUPAC name: (4R,5S)-3,5-dimethoxy-4-methyl-7-(2-{2-[(2S)-7-methylocta-3,5-dien-2-yl]-1,3-thiazol-4-yl}-1,3-thiazol-4-yl)hepta-2,6-dienamide
• IUPAC Traditional name: (4R,5S)-3,5-dimethoxy-4-methyl-7-(2-{2-[(2S)-7-methylocta-3,5-dien-2-yl]-1,3-thiazol-4-yl}-1,3-thiazol-4-yl)hepta-2,6-dienamide

DATABASE IDS

• MDL Number: MFCD00043397
• CAS Number: 76706-55-3

PROPERTIES

• Biological Source: from Myxococcus fulvus Mx f85
• Empirical Formula (Hill Notation): C25H33N3O3S2
• Purity: ≥98% (HPLC)
• Solubility: DMSO: soluble
• Solubility: acetone: soluble
• Solubility: chloroform: soluble
• Solubility: dichloromethane: soluble
• Solubility: ethanol: soluble
• Solubility: ethyl acetate: soluble
• Solubility: methanol: soluble
• GHS Signal Word: Danger
• GHS Hazard statements: H300
• European Hazard Symbols: Highly toxic (T+)
• GHS Precautionary statements: P264-P301 + P310
• Risk Statements: 28
• Safety Statements: 28-36/37-45
• Storage Condition: protect from light
• Storage Condition: under inert gas
• Storage Temperature: -20°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain.1 Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain.2,3 Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.4

Description (简体中文)

Biochem/physiol Actions
Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain.1 Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain.2,3 Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.4