SW02

• Catalog No.: S5951
• CAS Number: 1010820-68-4
• M. F.: C19H23BrN2O5
• M. W.: 439.30032
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: ethyl 4-(4-bromophenyl)-1-(4-methoxy-4-oxobutyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• IUPAC Traditional name: ethyl 4-(4-bromophenyl)-1-(4-methoxy-4-oxobutyl)-6-methyl-2-oxo-3,4-dihydropyrimidine-5-carboxylate
• Synonyms: 4-(4-Bromophenyl)-5-(ethoxycarbonyl)-3,4-dihydro-6-methyl-2-oxo-1(2H)-pyrimidinebutanoic acid methyl ester

DATABASE IDS

• MDL Number: MFCD17215960
• CAS Number: 1010820-68-4

PROPERTIES

• Empirical Formula (Hill Notation): C19H23BrN2O5
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: ≥20 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P301 + P310
• Risk Statements: 25
• Safety Statements: 45
• Storage Temperature: 2-8°C
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
SW02 is a specific activator/agonist of Hsp70. Hsp70 is of particular interest in diseases caused by protein misfolding, such as tau and Aβ in Alzheimer′s. SW02 increases Hsp70 ATPase activity, resulting in increased tau protein but not other disease-related proteins in cells. Hsp70 prevents aggregation of Aβ peptide, as shown by treatment with SW02.

Description (简体中文)

Biochem/physiol Actions
SW02 is a specific activator/agonist of Hsp70. Hsp70 is of particular interest in diseases caused by protein misfolding, such as tau and Aβ in Alzheimer′s. SW02 increases Hsp70 ATPase activity, resulting in increased tau protein but not other disease-related proteins in cells. Hsp70 prevents aggregation of Aβ peptide, as shown by treatment with SW02.