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VU0357017 monohydrochloride_Molecular_structure_CAS_1135242-13-5)
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VU0357017 monohydrochloride

Catalog No. V4640 Name Sigma Aldrich
CAS Number 1135242-13-5 Website http://www.sigmaaldrich.com
M. F. C18H28ClN3O3 Telephone 1-800-521-8956
M. W. 369.88622 Fax
Purity ≥98% (HPLC) Email
Storage Chembase ID: 154719

SYNONYMS

IUPAC name
ethyl 4-({2-[(2-methylphenyl)formamido]ethyl}amino)piperidine-1-carboxylate hydrochloride
IUPAC Traditional name
ethyl 4-({2-[(2-methylphenyl)formamido]ethyl}amino)piperidine-1-carboxylate hydrochloride
Synonyms
CID 25010775
4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride
ML071 hydrochloride
SID 56353039

DATABASE IDS

MDL Number MFCD17215959
CAS Number 1135242-13-5

PROPERTIES

Empirical Formula (Hill Notation) C18H27N3O3 · HCl
Purity ≥98% (HPLC)
Apperance white to off-white powder
Solubility DMSO: ≥10 mg/mL
European Hazard Symbols Nature polluting Nature polluting (N)
MSDS Link Download
Risk Statements 52/53
Safety Statements 61
Storage Temperature 2-8°C
German water hazard class 2

DETAILS

Description (English)
Biochem/physiol Actions
VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model.
Description (简体中文)
Biochem/physiol Actions
VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model.

REFERENCES