7,8-Dihydroxyflavone hydrate

• Catalog No.: D5446
• CAS Number: 38183-03-8(anhydrous)
• M. F.: C15H10O4
• M. W.: 254.2375
• Purity: ≥98% (HPLC)
• Storage: desiccated

SYNONYMS

• IUPAC name: 7,8-dihydroxy-2-phenyl-4H-chromen-4-one
• IUPAC Traditional name: 7,8-dihydroxy-2-phenylchromen-4-one

DATABASE IDS

• MDL Number: MFCD00006836
• EC Number: 253-812-4
• CAS Number: 38183-03-8(anhydrous)

PROPERTIES

• Empirical Formula (Hill Notation): C15H10O4 · xH2O
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: soluble24 mg/mL
• GHS Signal Word: Warning
• GHS Hazard statements: H302
• European Hazard Symbols: Harmful (Xn)
• Risk Statements: 22
• RTECS: DJ3004000
• Storage Condition: desiccated
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)-such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease-without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.1
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D5446.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Description (简体中文)

Biochem/physiol Actions
7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)-such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease-without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.1
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D5446.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.