Zafirlukast

• Catalog No.: Z4152
• CAS Number: 107753-78-6
• M. F.: C31H33N3O6S
• M. W.: 575.67522
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: cyclopentyl N-[3-({2-methoxy-4-[(2-methylbenzenesulfonyl)carbamoyl]phenyl}methyl)-1-methyl-1H-indol-5-yl]carbamate
• IUPAC Traditional name: zafirlukast
• Synonyms: N-[3-[[2-Methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]carbamic acid cyclopentyl ester

DATABASE IDS

• MDL Number: MFCD00864775
• CAS Number: 107753-78-6

PROPERTIES

• Empirical Formula (Hill Notation): C31H33N3O6S
• Purity: ≥98% (HPLC)
• Apperance: solid
• Solubility: DMSO: ≥28 mg/mL
• GHS Hazard statements: H413
• Storage Temperature: room temp
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
Zafirlukast is a potent subtype specific cysteinyl leukotriene type 1 receptor (CysLT1) antagonist; antiasthmatic. Zafirlukast has over 1000-fold selectivity for CysLT1, one of two receptors for cysteinyl leukotrienes LTC4, LTD4, and LTE4, which are important mediators of human bronchial asthma.

Description (简体中文)

Biochem/physiol Actions
Zafirlukast is a potent subtype specific cysteinyl leukotriene type 1 receptor (CysLT1) antagonist; antiasthmatic. Zafirlukast has over 1000-fold selectivity for CysLT1, one of two receptors for cysteinyl leukotrienes LTC4, LTD4, and LTE4, which are important mediators of human bronchial asthma.