5Z-7-Oxozeaenol

• Catalog No.: O9890
• CAS Number: 253863-19-3
• M. F.: C19H22O7
• M. W.: 362.37378
• Purity: ≥98% (HPLC)

SYNONYMS

• IUPAC name: (3S,8S,9S)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,7,8,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7-dione
• IUPAC Traditional name: (3S,8S,9S)-8,9,16-trihydroxy-14-methoxy-3-methyl-4,8,9,10-tetrahydro-3H-2-benzoxacyclotetradecine-1,7-dione
• Synonyms: FR148083; C 292; L 783279; F 152; LL-Z1640-2

DATABASE IDS

• MDL Number: MFCD12912700
• CAS Number: 253863-19-3

PROPERTIES

• Empirical Formula (Hill Notation): C19H22O7
• Purity: ≥98% (HPLC)
• Apperance: white to off-white powder
• Solubility: DMSO: >10 mg/mL
• GHS Signal Word: Danger
• GHS Hazard statements: H301
• European Hazard Symbols: Toxic (T)
• GHS Precautionary statements: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• Risk Statements: 25
• Safety Statements: 45
• Storage Temperature: 2-8°C
• Hazard Class: 6.1
• UN Number: 2811
• Packing Group: 3
• German water hazard class: 3

DETAILS

Description (English)

Biochem/physiol Actions
5Z-7-oxozeaenol is a potent ATP-competitive irreversible inhibitor of ERK2 (IC50= 80 nM), TAK1 (MKK7), and MEK1, which all contain a common cysteine residue in the ATP-binding site. It has no activity against other MAP kinases. 5Z-7-oxozeaenol is also anti-inflammatory.

Description (简体中文)

Biochem/physiol Actions
5Z-7-oxozeaenol is a potent ATP-competitive irreversible inhibitor of ERK2 (IC50= 80 nM), TAK1 (MKK7), and MEK1, which all contain a common cysteine residue in the ATP-binding site. It has no activity against other MAP kinases. 5Z-7-oxozeaenol is also anti-inflammatory.